seqCBS: CN Profiling using Sequencing and CBS. This is a method for DNA Copy Number Profiling using Next-Generation Sequencing. It has new model and test statistics based on non-homogeneous Poisson Processes with change point models. It uses an adaptation of Circular Binary Segmentation. Also included are methods for point-wise Bayesian Confidence Interval and model selection method for the change-point model. A case and a control sample reads (normal and tumor) are required.
References in zbMATH (referenced in 1 article )
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- Shen, Jeremy J.; Zhang, Nancy R.: Change-point model on nonhomogeneous Poisson processes with application in copy number profiling by next-generation DNA sequencing (2012)