TEQR: Target Equivalence Range Design. The target equivalence range (TEQR) design, previously named the toxicity equivalence range design is an up-down design patterned after the modified toxicity probability interval design.The TEQR design extends the well known 3+3 design to allow for: an explicit target range for the dose limiting toxicity (DLT) rate, more subjects at the maximum tolerated dose (MTD), and specification of a too-toxic rate, which closes a dose level, In addition, the TEQR design can be implemented to target a dose based either on toxicity rate or activity rate constrained for toxicity.
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- Sverdlov, Oleksandr; Wong, Weng Kee; Ryeznik, Yevgen: Adaptive clinical trial designs for phase I cancer studies (2014)