OPDOE: OPtimal Design Of Experiments. Experimental Design. ... Only a few of these packages are dedicated to design of experiments leaving several methods unimplemented. An attempt to fill some of these gaps regarding optimal design is made in Rasch et al. (Optimal experimental design with R. Chapman and Hall/CRC, Boca Raton, 2011) with its accompanying OPDOE library. While first versions of that library focused on getting the implementation of the algorithms done a new version with a somewhat simplified interface and improvements will be presented. The functions in the OPDOE library cover several topics of experimental design, including simple statistical tests, regression models, tests in analysis of variance models and sequential testing. The capabilities of the presented R library will be shown by a collection of examples covering these topics.