pocrm: Dose Finding in Drug Combination Phase I Trials Using PO-CRM. Provides functions to implement and simulate the partial order continual reassessment method (PO-CRM) for use in Phase I trials of combinations of agents. Provides a function for generating a set of initial guesses (skeleton) for the toxicity probabilities at each combination that correspond to the set of possible orderings of the toxicity probabilities specified by the user.

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  1. Sverdlov, Oleksandr; Wong, Weng Kee; Ryeznik, Yevgen: Adaptive clinical trial designs for phase I cancer studies (2014)