EWOC 2.0: interactive software for dose escalation in cancer phase I clinical trials. Escalation With Overdose Control (EWOC) version 2.0 is a publicly available freeware that uses Bayesian methods in a dose escalation scheme to assign dose levels sequentially to patients in cancer phase I clinical trials. The methodology is based on the optimal Bayesian-feasible procedure, which is designed to approach the maximum tolerated dose as fast as possible while controlling the probability of overdosing patients. This article describes the methodology as well as the development of the application program. Features of EWOC 2.0 are demonstrated.
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References in zbMATH (referenced in 4 articles )
Showing results 1 to 4 of 4.
- Sverdlov, Oleksandr; Wong, Weng Kee; Ryeznik, Yevgen: Adaptive clinical trial designs for phase I cancer studies (2014)
- Tighiouart, Mourad; Rogatko, André: Number of patients per cohort and sample size considerations using dose escalation with overdose control (2012)
- Tighiouart, Mourad; Rogatko, André: Dose finding with escalation with overdose control (EWOC) in cancer clinical trials (2010)
- Chu, Pei-Ling; Lin, Yong; Shih, Weichung Joe: Unifying CRM and EWOC designs for phase I cancer clinical trials (2009)