topologyGSA

topologyGSA: Gene Set Analysis Exploiting Pathway Topology. Using Gaussian graphical models we propose a novel approach to perform pathway analysis using gene expression. Given the structure of a graph (a pathway) we introduce two statistical tests to compare the mean and the concentration matrices between two groups. Specifically, these tests can be performed on the graph and on its connected components (cliques).

References in zbMATH (referenced in 1 article )

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  1. Djordjilović, Vera; Chiogna, Monica; Massa, M.Sofia; Romualdi, Chiara: Graphical modeling for gene set analysis: a critical appraisal (2015)