R package highSCREEN: High Throughput Screening for Plate Based Essays. Can be used to carry out extraction, normalization, quality control (QC), candidate hits identification and visualization for plate based essays, in drug discovery. This project was funded by the Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under contract No. HHSN272201400054C entitled ”Adjuvant Discovery For Vaccines Against West Nile Virus and Influenza”, awarded to Duke University and lead by Drs. Herman Staats and Soman Abraham.