R package VNM. Using V-algorithm and Newton-Raphson method to obtain multiple-objective optimal design for estimating the shape of dose-response, the ED50 (the dose producing an effect midway between the expected responses at the extreme doses) and the MED (the minimum effective dose level) for the 2,3,4-parameter logistic models and for evaluating its efficiencies for the three objectives.

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  1. Shen, Gang; Hyun, Seung Won; Wong, Weng Kee: Optimal designs based on the maximum quasi-likelihood estimator (2016)