R package Surrogate. In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package ’Surrogate’ allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union’s 7-th Framework Programme for research, technological development and demonstration under Grant Agreement no 602552.
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References in zbMATH (referenced in 3 articles )
Showing results 1 to 3 of 3.
- Alonso, Ariel; Van der Elst, Wim; Molenberghs, Geert; Buyse, Marc; Burzykowski, Tomasz: An information-theoretic approach for the evaluation of surrogate endpoints based on causal inference (2016)
- Buyse, Marc; Molenberghs, Geert; Paoletti, Xavier; Oba, Koji; Alonso, Ariel; Der Elst, Wim van; Burzykowski, Tomasz: Statistical evaluation of surrogate endpoints with examples from cancer clinical trials (2016)
- Alonso, Ariel; van der Elst, Wim; Molenberghs, Geert; Buyse, Marc; Burzykowski, Tomasz: On the relationship between the causal-inference and meta-analytic paradigms for the validation of surrogate endpoints (2015)