Memtype-2L: a web server for predicting membrane proteins and their types by incorporating evolution information through pse-PSSM. Given an uncharacterized protein sequence, how can we identify whether it is a membrane protein or not? If it is, which membrane protein type it belongs to? These questions are important because they are closely relevant to the biological function of the query protein and to its interaction process with other molecules in a biological system. Particularly, with the avalanche of protein sequences generated in the Post-Genomic Age and the relatively much slower progress in using biochemical experiments to determine their functions, it is highly desired to develop an automated method that can be used to help address these questions. In this study, a 2-layer predictor, called MemType-2L, has been developed: the 1st layer prediction engine is to identify a query protein as membrane or non-membrane; if it is a membrane protein, the process will be automatically continued with the 2nd-layer prediction engine to further identify its type among the following eight categories: (1) type I, (2) type II, (3) type III, (4) type IV, (5) multipass, (6) lipid-chain-anchored, (7) GPI-anchored, and (8) peripheral. MemType-2L is featured by incorporating the evolution information through representing the protein samples with the Pse-PSSM (Pseudo Position-Specific Score Matrix) vectors, and by containing an ensemble classifier formed by fusing many powerful individual OET-KNN (Optimized Evidence-Theoretic K-Nearest Neighbor) classifiers. The success rates obtained by MemType-2L on a new-constructed stringent dataset by both the jackknife test and the independent dataset test are quite high, indicating that MemType-2L may become a very useful high throughput tool. As a Web server, MemType-2L is freely accessible to the public at

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  1. Ahmad, Jamal; Hayat, Maqsood: MFSC: multi-voting based feature selection for classification of Golgi proteins by adopting the general form of Chou’s PseAAC components (2019)
  2. Butt, Ahmad Hassan; Rasool, Nouman; Khan, Yaser Daanial: Prediction of antioxidant proteins by incorporating statistical moments based features into Chou’s PseAAC (2019)
  3. Arif, Muhammad; Hayat, Maqsood; Jan, Zahoor: IMem-2LSAAC: a two-level model for discrimination of membrane proteins and their types by extending the notion of SAAC into Chou’s pseudo amino acid composition (2018)
  4. Cheng, Xiang; Xiao, Xuan; Chou, Kuo-Chen: pLoc_bal-mGneg: predict subcellular localization of Gram-negative bacterial proteins by quasi-balancing training dataset and general PseAAC (2018)
  5. Qiu, Wenying; Li, Shan; Cui, Xiaowen; Yu, Zhaomin; Wang, Minghui; Du, Junwei; Peng, Yanjun; Yu, Bin: Predicting protein submitochondrial locations by incorporating the pseudo-position specific scoring matrix into the general Chou’s pseudo-amino acid composition (2018)
  6. Sankari, E. Siva; Manimegalai, D.: Predicting membrane protein types by incorporating a novel feature set into Chou’s general PseAAC (2018)
  7. Khan, Muslim; Hayat, Maqsood; Khan, Sher Afzal; Ahmad, Saeed; Iqbal, Nadeem: Bi-PSSM: position specific scoring matrix based intelligent computational model for identification of mycobacterial membrane proteins (2017)
  8. Saghapour, Ehsan; Sehhati, Mohammadreza: Prediction of metastasis in advanced colorectal carcinomas using CGH data (2017)
  9. Ali, Farman; Hayat, Maqsood: Classification of membrane protein types using voting feature interval in combination with Chou’s pseudo amino acid composition (2015)
  10. Samal, Himanshu Bhusan; Prava, Jyoti; Suar, Mrutyunjay; Mahapatra, Rajani Kanta: Comparative genomics study of \textitSalmonellaTyphimurium LT2 for the identification of putative therapeutic candidates (2015)
  11. Han, Guo-Sheng; Yu, Zu-Guo; Anh, Vo: A two-stage SVM method to predict membrane protein types by incorporating amino acid classifications and physicochemical properties into a general form of Chou’s PseAAC (2014)
  12. Lyons, James; Biswas, Neela; Sharma, Alok; Dehzangi, Abdollah; Paliwal, Kuldip K.: Protein fold recognition by alignment of amino acid residues using kernelized dynamic time warping (2014)
  13. Chen, Yen-Kuang; Li, Kuo-Bin: Predicting membrane protein types by incorporating protein topology, domains, signal peptides, and physicochemical properties into the general form of Chou’s pseudo amino acid composition (2013)
  14. Huang, Chao; Yuan, Jing-Qi: Predicting protein subchloroplast locations with both single and multiple sites via three different modes of Chou’s pseudo amino acid compositions (2013)
  15. Fan, Guo-Liang; Li, Qian-Zhong: Predicting mycobacterial proteins subcellular locations by incorporating pseudo-average chemical shift into the general form of Chou’s pseudo amino acid composition (2012)
  16. Hayat, Maqsood; Khan, Asifullah: MemHyb: predicting membrane protein types by hybridizing SAAC and PSSM (2012)
  17. Li, Tao; Li, Qian-Zhong: Annotating the protein-RNA interaction sites in proteins using evolutionary information and protein backbone structure (2012)
  18. Yang, Lianping; Zhang, Xiangde; Zhu, Hegui: Alignment free comparison: similarity distribution between the DNA primary sequences based on the shortest absent word (2012)
  19. Chou, Kuo-Chen: Some remarks on protein attribute prediction and pseudo amino acid composition (2011)
  20. González-Díaz, Humberto; Prado-Prado, Francisco; Sobarzo-Sánchez, Eduardo; Haddad, Mohamed; Maurel Chevalley, Séverine; Valentin, Alexis; Quetin-Leclercq, Joëlle; Dea-Ayuela, María A.; Gomez-Muños, María Teresa; Munteanu, Cristian R.; Torres-Labandeira, Juan José; García-Mera, Xerardo; Tapia, Ricardo A.; Ubeira, Florencio M.: NL MIND-BEST: a web server for ligands and proteins discovery -- theoretic-experimental study of proteins of \textitGiardialamblia and new compounds active against \textitPlasmodiumfalciparum (2011)

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