R package BIGDAWG. Data sets and functions for chi-squared Hardy-Weinberg and case-control association tests of highly polymorphic genetic data [e.g., human leukocyte antigen (HLA) data]. Performs association tests at multiple levels of polymorphism (haplotype, locus and HLA amino-acids) as described in Pappas DJ, Marin W, Hollenbach JA, Mack SJ (2016) &lt;<a href=””>doi:10.1016/j.humimm.2015.12.006</a>&gt;. Combines rare variants to a common class to account for sparse cells in tables as described by Hollenbach JA, Mack SJ, Thomson G, Gourraud PA (2012) &lt;<a href=””>doi:10.1007/978-1-61779-842-9_14</a>&gt;.

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