GeneWise and Genomewise. We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.

References in zbMATH (referenced in 5 articles )

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  1. Erciyes, K.: Distributed and sequential algorithms for bioinformatics (2015)
  2. Yok, Non G.; Rosen, Gail L.: Combining gene prediction methods to improve metagenomic gene annotation (2011) ioport
  3. Liang, Chunguang; Schmid, Alexander; López-Sánchez, María José; Moya, Andres; Gross, Roy; Bernhardt, Jörg; Dandekar, Thomas: JANE: efficient mapping of prokaryotic ests and variable length sequence reads on related template genomes (2009) ioport
  4. Schreiber, Fabian; Pick, Kerstin; Erpenbeck, Dirk; Wörheide, Gert; Morgenstern, Burkhard: Orthoselect: a protocol for selecting orthologous groups in phylogenomics (2009) ioport
  5. Zhang, Linxi; Chen, Jin: Scaling behaviors of CG clusters in coding and noncoding DNA sequences (2005)