ConSeq: the identification of functionally and structurally important residues in protein sequences. Motivation: ConSeq is a web server for the identification of biologically important residues in protein sequences. Functionally important residues that take part, e.g. in ligand binding and protein–protein interactions, are often evolutionarily conserved and are most likely to be solvent-accessible, whereas conserved residues within the protein core most probably have an important structural role in maintaining the protein’s fold. Thus, estimated evolutionary rates, as well as relative solvent accessibility predictions, are assigned to each amino acid in the sequence; both are subsequently used to indicate residues that have potential structural or functional importance. Availability: The ConSeq web server is available at

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References in zbMATH (referenced in 4 articles )

Showing results 1 to 4 of 4.
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  1. Guharoy, Mainak; Chakrabarti, Pinak: Conserved residue clusters at protein-protein interfaces and their use in binding site identification (2010) ioport
  2. Rahbar, Mohammad Reza; Rasooli, Iraj; Mousavi Gargari, Seyed Latif; Amani, Jafar; Fattahian, Yaser: In silico analysis of antibody triggering biofilm associated protein in \textitAcinetobacterbaumannii (2010)
  3. Hernandez-Mendoza, Armando; Quinto, Carmen; Segovia, Lorenzo; Perez-Rueda, Ernesto: Ligand-binding prediction in the resistance-nodulation-cell division (RND) proteins (2007)
  4. Livesay, Dennis R.; Kidd, Patrick D.; Eskandari, Sepehr; Roshan, Usman: Assessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study analyzing the neurotransmitter/Na^+ symporter family (2007) ioport