# someKfwer

k-FWER control without $p$-value adjustment, with application to detection of genetic determinants of multiple sclerosis in Italian twins. We show a novel approach for k-Familywise Error Rate (k-FWER) control which does not involve any correction, but only testing the hypotheses along a (possibly data-driven) order until a suitable number of p-values are found above the uncorrected α level. p-values can arise from any linear model in a parametric or nonparametric setting. The approach is not only very simple and computationally undemanding, but also the data-driven order enhances power when the sample size is small (and also when k and/or the number of tests is large). We illustrate the method on an original study about gene discovery in multiple sclerosis, in which were involved a small number of couples of twins, discordant by disease. The methods are implemented in an 𝐑 package (someKfwer), freely available on CRAN. (Source: http://cran.r-project.org/web/packages)

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## References in zbMATH (referenced in 2 articles , 1 standard article )

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