Refplus: an r package extending the rma algorithm. RMA has become a widely used methodology to preprocess Affymetrix gene expression microarrays. A limitation of RMA is that the calculated probeset intensities change when a set of microarrays is re-pre-processed after the inclusion of additional microarrays into the analysis set. Here we report the availability of the RefPlus package containing functions to perform the Extrapolation Strategy and Extrapolation Averaging algorithms which address these issues. The software is implemented in the R language and can be downloaded from the Bioconductor project website (

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References in zbMATH (referenced in 2 articles )

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  1. Guzzi, Pietro H.; Di Martino, Maria Teresa; Tradigo, Giuseppe; Veltri, Pierangelo; Tassone, Pierfrancesco; Tagliaferri, Pierosandro; Cannataro, Mario: Automatic summarisation and annotation of microarray data (2011) ioport
  2. Harbron, Chris; Chang, Kai-Ming; South, Marie C.: Refplus: An r package extending the rma algorithm (2007) ioport