NONMEM® is a nonlinear mixed effects modelling tool used in population pharmacokinetic/pharmacodynamic analysis. NONMEM stands for NONlinear Mixed Effects Modeling. NONMEM is a computer program that is implemented in Fortran90/95. It solves pharmaceutical statistical problems in which within subject and between subjects variability is taken into account when fitting a pharmacokinetic and/or pharmacodynamic (PK/PD) model to data. The appropriate statistical analysis using the appropriate model helps pharmaceutical companies determine appropriate dosing strategies for their products, and increases their understanding of drug mechanisms and interactions.NONMEM software was originally developed by Lewis Sheiner and Stuart Beal and the NONMEM Project Group at the University of California, and has been used for over 30 years for population analysis by many pharmaceutical companies and the PK/PD modeling community. Its continued development and improvement by ICON Development Solutions assures pharmaceutical companies that they may continue to use the analysis tool with which they are familiar for present day pharmaceutical development.

References in zbMATH (referenced in 21 articles )

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  1. Heinzl, Felix; Tutz, Gerhard: Additive mixed models with approximate Dirichlet process mixtures: the EM approach (2016)
  2. Vinogradova, Svetlana V.; Zhudenkov, Kirill V.; Benson, Neil; Van Der Graaf, Piet H.; Demin, Oleg V.; Karelina, Tatiana A.: Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis (2015)
  3. Gudmand-Hoeyer, Johanne; Timmermann, Stine; Ottesen, Johnny T.: Patient-specific modeling of the neuroendocrine HPA-axis and its relation to depression: ultradian and Circadian oscillations (2014)
  4. Wang, L.; Cao, J.; Ramsay, J.O.; Burger, D.M.; Laporte, C.J.L.; Rockstroh, J.K.: Estimating mixed-effects differential equation models (2014)
  5. Demidenko, Eugene: Mixed models. Theory and applications with R (2013)
  6. Antic, J.; Laffont, C.M.; Chafaï, D.; Concordet, D.: Comparison of nonparametric methods in nonlinear mixed effects models (2009)
  7. Crespi, Catherine M.; Boscardin, W.John: Bayesian model checking for multivariate outcome data (2009)
  8. Pillonetto, Gianluigi; de Nicolao, Giuseppe; Chierici, Marco; Cobelli, Claudio: Fast algorithms for nonparametric population modeling of large data sets (2009)
  9. Freijer, Jan I.; Post, Teun M.; Ploeger, Bart A.; Dejongh, Joost; Danhof, Meindert: Application of the convection-dispersion equation to modelling oral drug absorption (2007)
  10. Neve, M.; De Nicolao, G.; Marchesi, L.: Nonparametric identification of population models via Gaussian processes (2007)
  11. Wang, Xiaoning; Schumitzky, Alan; D’Argenio, David Z.: Nonlinear random effects mixture models: maximum likelihood estimation via the EM algorithm (2007)
  12. Verotta, Davide: Models and estimation methods for clinical HIV-1 data (2005)
  13. Ge, Zhiyu; Bickel, Peter J.; Rice, John A.: An approximate likelihood approach to nonlinear mixed effects models via spline approximation (2004)
  14. Lee, Sik-Yum; Xu, Liang: Influence analyses of nonlinear mixed-effects models (2004)
  15. Concordet, Didier; Nunez, Olivier G.: A simulated pseudo-maximum likelihood estimator for nonlinear mixed models. (2002)
  16. Verotta, Davide; Schaedeli, Franziska: Non-linear dynamics models characterizing long-term virological data from AIDS clinical trials (2002)
  17. Bell, Bradley M.: Approximating the marginal likelihood estimate for models with random parameters (2001)
  18. Hartford, A.; Davidian, M.: Consequences of misspecifying assumptions in nonlinear mixed effects models. (2000)
  19. Sheiner, Lewis B.; Beal, Stuart L.; Dunne, Adrian: Analysis of nonrandomly censored ordered categorical longitudinal data from analgesic trials. (With discussion) (1997)
  20. Wolfinger, Russell D.; Lin, Xihong: Two Taylor-series approximation methods for nonlinear mixed models (1997)

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