The project SimBio-”A generic environment for bio-numerical simulation” (IST-1999-10378)-is a European project from a Fifth Framework Programme, within thematic programme ”User-friendly information society” (IST). The central objective of the ongoing SimBio project (IST-1999-10378) activities is the improvement of clinical and medical practices by the use of numerical simulation for bio-medical problems - ”bio-numerical simulation”. Building on existing experience with particular applications, a generic simulation environment will be produced which will provide an innovative enabling technology for advanced clinical practice and health care. A key feature in the SimBio project is the possibility to use individual patient data as input to the modelling and simulation process.