A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. We propose a family-based association test, FBAT-PC, for studies with quantitative traits that are measured repeatedly. The traits may be influenced by partially or completely unknown factors that may vary for each measurement. Using generalized principal component analysis, FBAT-PC amplifies the genetic effects of each measurement by constructing an overall phenotype with maximal heritability. Analytically, and in the simulation studies, we compare FBAT-PC with standard methodology and assess both the heritability of the overall phenotype and the power of FBAT-PC. Compared to univariate analysis, FBAT-PC achieves power gains of up to 200%. Applications of FBAT-PC to an osteoporosis study and to an asthma study show the practical relevance of FBAT-PC. FBAT-PC has been implemented in the software package PBAT and is freely available at http://www.biostat.harvard.edu/ clange/default.htm.
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References in zbMATH (referenced in 6 articles )
Showing results 1 to 6 of 6.
- Yun-Hee Choi, Laurent Briollais, Wenqing He, Karen Kopciuk: FamEvent: An R Package for Generating and Modeling Time-to-Event Data in Family Designs (2021) not zbMATH
- Duan, Faping; Ogden, Daniel; Xu, Ling; Liu, Kang; Lust, George; Sandler, Jody; Dykes, Nathan L.; Zhu, Lan; Harris, Steven; Jones, Paul; Todhunter, Rory J.; Zhang, Zhiwu: Principal component analysis of canine hip dysplasia phenotypes and their statistical power for genome-wide association mapping (2013)
- Yang, Qiong; Wang, Yuanjia: Methods for analyzing multivariate phenotypes in genetic association studies (2012)
- Laird, Nan M.; Lange, Christoph: The role of family-based designs in genome-wide association studies (2009)
- Lange, Christoph; van Steen, Kristel; Andrew, Toby; et al.: A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects (2004)
- Murphy, Amy; Van Steen, Kristel; Lange, Christoph: On missing phenotype data in multivariate family based association tests: FBAT-GEE-IMP and imputation strategies based on the EM-algorithm, the DA-algorithm and the conditional mean model (2004)