CHeart is a scientific software application for simulating the physics of the human heart. CHeart is used to simulate the mechanical physics, fluid dynamics, and electrophysiology of the heart, allowing scientists and physicians to study the properties of the heart. CHeart combines fast, scaling code which leverages the most advanced supercomputing resources available, as well as the leading edge of GPU computational technologies. CHeart is a multi-disciplinary effort between scientists, physicians, and software engineers at the Biomedical Engineering Department of King’s College in London, UK.