The Applied Partial Differential Equations Center (APDEC): an Integrated Software Infrastructure Center for Block-Structured Adaptive Mesh Refinement. The goal of this project is to develop a high-performance algorithmic and software framework for multi-scale problems in three important DOE mission areas (magnetic fusion, accelerator design, and combustion) based on the use of block-structured adaptive mesh refinement (AMR) for representing multiple scales. We are taking an end-to-end approach to applying AMR to these problem areas, developing new self-contained simulation capabilities in collaboration with investigators in the applications fields.