surrosurv

R package surrosurv. Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses. Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) <<a href=”http://dx.doi.org/10.1111/1467-9876.00244”>doi:10.1111/1467-9876.00244</a>> with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM.