MultiP-SChlo: multi-label protein subchloroplast localization prediction with Chous pseudo amino acid composition and a novel multi-label classifier. Motivation: Identifying protein subchloroplast localization in chloroplast organelle is very helpful for understanding the function of chloroplast proteins. There have existed a few computational prediction methods for protein subchloroplast localization. However, these existing works have ignored proteins with multiple subchloroplast locations when constructing prediction models, so that they can predict only one of all subchloroplast locations of this kind of multilabel proteins. Results: To address this problem, through utilizing label-specific features and label correlations simultaneously, a novel multilabel classifier was developed for predicting protein subchloroplast location(s) with both single and multiple location sites. As an initial study, the overall accuracy of our proposed algorithm reaches 55.52%, which is quite high to be able to become a promising tool for further studies. Availability and implementation: An online web server for our proposed algorithm named MultiP-SChlo was developed, which are freely accessible at

References in zbMATH (referenced in 8 articles )

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  1. Shen, Yinan; Tang, Jijun; Guo, Fei: Identification of protein subcellular localization via integrating evolutionary and physicochemical information into Chou’s general PseAAC (2019)
  2. Zhao, Wei; Li, Guang-Ping; Wang, Jun; Zhou, Yuan-Ke; Gao, Yang; Du, Pu-Feng: Predicting protein sub-Golgi locations by combining functional domain enrichment scores with pseudo-amino acid compositions (2019)
  3. Vluymans, Sarah; Cornelis, Chris; Herrera, Francisco; Saeys, Yvan: Multi-label classification using a fuzzy rough neighborhood consensus (2018)
  4. Jia, Jianhua; Liu, Zi; Xiao, Xuan; Liu, Bingxiang; Chou, Kuo-Chen: pSuc-Lys: predict lysine succinylation sites in proteins with PseAAC and ensemble random forest approach (2016)
  5. Jiao, Ya-Sen; Du, Pu-Feng: Predicting Golgi-resident protein types using pseudo amino acid compositions: approaches with positional specific physicochemical properties (2016)
  6. Yang, Lianping; Zhang, Xiangde; Fu, Haoyue; Yang, Chenhui: An estimator for local analysis of genome based on the minimal absent word (2016)
  7. Ju, Zhe; Cao, Jun-Zhe; Gu, Hong: iLM-2L: a two-level predictor for identifying protein lysine methylation sites and their methylation degrees by incorporating K-gap amino acid pairs into Chou’s general PseAAC (2015)
  8. Wan, Shibiao; Mak, Man-Wai; Kung, Sun-Yuan: mLASSO-Hum: a LASSO-based interpretable human-protein subcellular localization predictor (2015)