joineRML

R package joineRML. Joint Modelling of Multivariate Longitudinal Data and Time-to-Event Outcomes. Fits the joint model proposed by Henderson and colleagues (2000) <<a href=”http://dx.doi.org/10.1093/biostatistics/1.4.465”>doi:10.1093/biostatistics/1.4.465</a>>, but extended to the case of multiple continuous longitudinal measures. The time-to-event data is modelled using a Cox proportional hazards regression model with time-varying covariates. The multiple longitudinal outcomes are modelled using a multivariate version of the Laird and Ware linear mixed model. The association is captured by a multivariate latent Gaussian process. The model is estimated using a Monte Carlo Expectation Maximization algorithm. This project is funded by the Medical Research Council (Grant number MR/M013227/1).