UniProt: a hub for protein information. UniProt is an important collection of protein sequences and their annotations, which has doubled in size to 80 million sequences during the past year. This growth in sequences has prompted an extension of UniProt accession number space from 6 to 10 characters. An increasing fraction of new sequences are identical to a sequence that already exists in the database with the majority of sequences coming from genome sequencing projects. We have created a new proteome identifier that uniquely identifies a particular assembly of a species and strain or subspecies to help users track the provenance of sequences. We present a new website that has been designed using a user-experience design process. We have introduced an annotation score for all entries in UniProt to represent the relative amount of knowledge known about each protein. These scores will be helpful in identifying which proteins are the best characterized and most informative for comparative analysis. All UniProt data is provided freely and is available on the web at http://www.uniprot.org/.

References in zbMATH (referenced in 136 articles , 1 standard article )

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  1. Chang, Darby Tien-Hao; Syu, Yu-Tang; Lin, Po-Chang: Predicting the protein-protein interactions using primary structures with predicted protein surface (2010) ioport
  2. Chen, Chuming; McGarvey, Peter B.; Huang, Hongzhan; Wu, Cathy H.: Protein bioinformatics infrastructure for the integration and analysis of multiple high-throughput “omics” data (2010) ioport
  3. Davey, Norman E.; Edwards, Richard J.; Shields, Denis C.: Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated proteins (2010) ioport
  4. Kim, Seonho; Yoon, Juntae; Yang, Jihoon; Park, Seog: Walk-weighted subsequence kernels for protein-protein interaction extraction (2010) ioport
  5. Lin, Yi-Ruen; Wei, Hsin-Yuan; Tsai, Tsung-Lin; Lin, Thy-Hou: HDAPD: a web tool for searching the disease-associated protein structures (2010) ioport
  6. Malik, Adeel; Firoz, Ahmad; Jha, Vivekanand; Ahmad, Shandar: PROCARB: a database of known and modelled carbohydrate-binding protein structures with sequence-based prediction tools (2010) ioport
  7. Masso, Majid; Vaisman, Iosif I.: Knowledge-based computational mutagenesis for predicting the disease potential of human non-synonymous single nucleotide polymorphisms (2010)
  8. Penner, R. C.; Knudsen, Michael; Wiuf, Carsten; Andersen, Jørgen Ellegaard: Fatgraph models of proteins (2010)
  9. Roslan, Rosfuzah; Othman, Razib M.; Shah, Zuraini A.; Kasim, Shahreen; Asmuni, Hishammuddin; Taliba, Jumail; Hassan, Rohayanti; Zakaria, Zalmiyah: Incorporating multiple genomic features with the utilization of interacting domain patterns to improve the prediction of protein-protein interactions (2010) ioport
  10. Someya, Seizi; Kakuta, Masanori; Morita, Mizuki; Sumikoshi, Kazuya; Cao, Wei; Ge, Zhenyi; Hirose, Osamu; Nakamura, Shugo; Terada, Tohru; Shimizu, Kentaro: Prediction of carbohydrate-binding proteins from sequences using support vector machines (2010)
  11. Towfic, Fadi; Vanderplas, Susan; Oliver, Casey A.; Couture, Oliver; Tuggle, Christopher K.; Greenlee, M. Heather West; Honavar, Vasant: Detection of gene orthology from gene co-expression and protein interaction networks (2010) ioport
  12. Warren, Andrew S.; Archuleta, Jeremy S.; Feng, Wu-Chun; Setubal, João Carlos: Missing genes in the annotation of prokaryotic genomes (2010) ioport
  13. Yu, Shi; Tranchevent, Léon-Charles; De Moor, Bart; Moreau, Yves: Gene prioritization and clustering by multi-view text mining (2010) ioport
  14. Alterovitz, Ron; Arvey, Aaron; Sankararaman, Sriram; Dallett, Carolina; Freund, Yoav; Sjölander, Kimmen: Resboost: characterizing and predicting catalytic residues in enzymes (2009) ioport
  15. Anwar, Nadia; Hunt, Ela: \textitfrancisellatularensis novicidaproteomic and transcriptomic data integration and annotation based on semantic web technologies (2009) ioport
  16. Arakawa, Kazuharu; Tamaki, Satoshi; Kono, Nobuaki; Kido, Nobuhiro; Ikegami, Keita; Ogawa, Ryu; Tomita, Masaru: Genome projector: zoomable genome map with multiple views (2009) ioport
  17. Arrial, Roberto T.; Togawa, Roberto C.; Brigido, Marcelo M.: Screening non-coding rnas in transcriptomes from neglected species using PORTRAIT: case study of the pathogenic fungus paracoccidioides brasiliensis (2009) ioport
  18. Blum, Torsten; Briesemeister, Sebastian; Kohlbacher, Oliver: Multiloc2: integrating phylogeny and gene ontology terms improves subcellular protein localization prediction (2009) ioport
  19. Brown, J. B.; Akutsu, Tatsuya: Identification of novel DNA repair proteins via primary sequence, secondary structure, and homology (2009) ioport
  20. Buske, Fabian A.; Maetschke, Stefan; Bodén, Mikael: It’s about time: signal recognition in staged models of protein translocation (2009)