Quat-2L: a web-server for predicting protein quaternary structural attributes. By hybridizing the functional-domain and sequence-correlated pseudo amino acid composition approaches, a 2-layer predictor called ”Quat-2L” was developed for predicting the quaternary structural attribute of a protein according to its sequence information alone. The 1st layer is to identify the query protein as monomer, homo-oligomer, or hetero-oligomer. If the result thus obtained turns out to be homo-oligomer or hetero-oligomer, then the prediction will be automatically continued to further identify it belonging to one of the following six subtypes: (1) dimer, (2) trimer, (3) tetramer, (4) pentamer, (5) hexamer, and (6) octamer. The overall success rate of Quat-2L for the 1st layer identification was 71.14%; while the overall success rates of the 2nd layer for homo-oligomers and hetero-oligomers were 76.91 and 82.52%, respectively. These rates were derived by the jackknife cross-validation tests on the stringent benchmark data set in which none of proteins has ≥ 60% pairwise sequence identity to any other in the same subset. As a web-server, Quat-2L is freely accessible to the public via http://icpr.jci.jx.cn/bioinfo/Quat-2L, where one can get 2-level results in about 15 s.

References in zbMATH (referenced in 15 articles )

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  1. Srivastava, Abhishikha; Kumar, Ravindra; Kumar, Manish: BlaPred: predicting and classifying (\beta)-lactamase using a 3-tier prediction system via Chou’s general PseAAC (2018)
  2. Xiao, Xuan; Min, Jian-Liang; Wang, Pu; Chou, Kuo-Chen: iCDI-PseFpt: identify the channel-drug interaction in cellular networking with PseAAC and molecular fingerprints (2013)
  3. Liu, Guoqing; Liu, Jia; Cui, Xiangjun; Cai, Lu: Sequence-dependent prediction of recombination hotspots in \textitSaccharomycescerevisiae (2012)
  4. Lu, Jin-Long; Hu, Xue-Hai; Hu, Dong-Gang: A new hybrid fractal algorithm for predicting thermophilic nucleotide sequences (2012)
  5. Qiu, Zhijun; Wang, Xicheng: Prediction of protein-protein interaction sites using patch-based residue characterization (2012)
  6. Cheng, Feng; Theodorescu, Dan; Schulman, Ira G.; Lee, Jae K.: \textitInvitro transcriptomic prediction of hepatotoxicity for early drug discovery (2011)
  7. Chou, Kuo-Chen: Some remarks on protein attribute prediction and pseudo amino acid composition (2011)
  8. de Avila e Silva, Scheila; Echeverrigaray, Sergio; Gerhardt, Günther J. L.: BacPP: bacterial promoter prediction -- a tool for accurate sigma-factor specific assignment in enterobacteria (2011)
  9. González-Díaz, Humberto; Prado-Prado, Francisco; Sobarzo-Sánchez, Eduardo; Haddad, Mohamed; Maurel Chevalley, Séverine; Valentin, Alexis; Quetin-Leclercq, Joëlle; Dea-Ayuela, María A.; Gomez-Muños, María Teresa; Munteanu, Cristian R.; Torres-Labandeira, Juan José; García-Mera, Xerardo; Tapia, Ricardo A.; Ubeira, Florencio M.: NL MIND-BEST: a web server for ligands and proteins discovery -- theoretic-experimental study of proteins of \textitGiardialamblia and new compounds active against \textitPlasmodiumfalciparum (2011)
  10. Mohabatkar, Hassan; Mohammad Beigi, Majid; Esmaeili, Abolghasem: Prediction of GABA(_\mathrmA) receptor proteins using the concept of Chou’s pseudo-amino acid composition and support vector machine (2011)
  11. Qi, Zhao-Hui; Li, Ling; Zhang, Zhi-Meng; Qi, Xiao-Qin: Self-similarity analysis of eubacteria genome based on weighted graph (2011)
  12. Xiao, Xuan; Wu, Zhi-Cheng; Chou, Kuo-Chen: \textbfiLoc-Virus: a multi-label learning classifier for identifying the subcellular localization of virus proteins with both single and multiple sites (2011)
  13. Zhou, Guo-Ping: The disposition of the LZCC protein residues in wenxiang diagram provides new insights into the protein-protein interaction mechanism (2011)
  14. Georgiou, D. N.; Karakasidis, T. E.; Nieto, Juan J.; Torres, A.: A study of entropy/clarity of genetic sequences using metric spaces and fuzzy sets (2010)
  15. Masso, Majid; Vaisman, Iosif I.: Knowledge-based computational mutagenesis for predicting the disease potential of human non-synonymous single nucleotide polymorphisms (2010)