CATH: comprehensive structural and functional annotations for genome sequences. The latest version of the CATH-Gene3D protein structure classification database (4.0, provides annotations for over 235,000 protein domain structures and includes 25 million domain predictions. This article provides an update on the major developments in the 2 years since the last publication in this journal including: significant improvements to the predictive power of our functional families (FunFams); the release of our ’current’ putative domain assignments (CATH-B); a new, strictly non-redundant data set of CATH domains suitable for homology benchmarking experiments (CATH-40) and a number of improvements to the web pages.

References in zbMATH (referenced in 3 articles )

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  1. Zhao, Yun; He, Jianfeng; Li, Jing: The structural modeling of EF-hand motifs in parvalbumin (2018)
  2. Keith, Jonathan M. (ed.): Bioinformatics. Volume I. Data, sequence analysis, and evolution (2017)
  3. Cheng, Jianlin; Sweredoski, Michael J.; Baldi, Pierre: DOMpro: protein domain prediction using profiles, secondary structure, relative solvent accessibility, and recursive neural networks (2006) ioport