A Separation Logic Framework for Imperative HOL. We provide a framework for separation-logic based correctness proofs of Imperative HOL programs. Our framework comes with a set of proof methods to automate canonical tasks such as verification condition generation and frame inference. Moreover, we provide a set of examples that show the applicability of our framework. The examples include algorithms on lists, hash-tables, and union-find trees. We also provide abstract interfaces for lists, maps, and sets, that allow to develop generic imperative algorithms and use data-refinement techniques. As we target Imperative HOL, our programs can be translated to efficiently executable code in various target languages, including ML, OCaml, Haskell, and Scala.