R package ordcrm: Likelihood-Based Continual Reassessment Method (CRM) Dose Finding Designs. Provides the setup and calculations needed to run a likelihood-based continual reassessment method (CRM) dose finding trial and performs simulations to assess design performance under various scenarios. 3 dose finding designs are included in this package: ordinal proportional odds model (POM) CRM, ordinal continuation ratio (CR) model CRM, and the binary 2-parameter logistic model CRM. These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose-limiting toxicity (DLT) rates, discrete or continuous dose levels, combining ordinal grades 0 and 1 into one category, and incorporate safety and/or stopping rules. For POM and CR model designs, ordinal toxicity grades are specified by common terminology criteria for adverse events (CTCAE) version 4.0. Function ’pseudodata’ creates the necessary starting models

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  1. Daniel Sabanés Bové, Wai Yin Yeung, Giuseppe Palermo, Thomas Jaki: Model-Based Dose Escalation Designs in R with crmPack (2019) not zbMATH