BioPreDyn-Bench is a suite of benchmark problems for dynamic modelling in systems biology. BioPreDyn-Bench has been developed in the framework of BioPreDyn, an EU FP7 Cooperation project (Knowledge Based Bio-Economy, KBBE EU grant number 289434). BioPreDyn partners are developing data-driven computational models to analyze multi-scale biological networks, creating tools to help design and optimize complex biotechnological processes.