COILCHECK + is a webserver that can be used to measure the strength of interactions between helices involved in coiled-coils. The interactions are measured using standard energy calculations involving non-bonded and electrostatic interactions and for the presence of hydrogen bonds and salt bridges. The sum of these interactions is expressed as psuedoenergy, whose ranges have been standardized using known structural entries that contain coiled coils. Such an energy measure is quite useful for assessing the energy of dimers that are likely to form coiled-coils, can help to rationalise point mutations and can also help to design experiments.

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  1. Zhang, Zhe; Miteva, Maria A.; Wang, Lin; Alexov, Emil: Analyzing effects of naturally occurring missense mutations (2012)