XPEB

XPEB: This R package implements the cross-population empirical Bayes method, XPEB, described in Coram et al. AJHG 2015. XPEB takes as input P-value summary statistics from two GWAS, a target-GWAS from for example an ethnic minority population of primary interest and an auxiliary base-GWAS such as a larger GWAS in Europeans, and reprioritizes SNPs in the target population to compute local false discovery rates. XPEB also estimates the degree of overlap in the genetic architecture underlying the trait between the two populations. Reference: Coram MA, Candille SI, Duan Q, Chan KHK, Li Y, Kooperberg C, Reiner AP, Tang H. (2015) Leveraging Multi-ethnic Evidence for Mapping Complex Traits in Minority Populations: An Empirical Bayes Approach. Am J Hum Genet 96:740-52.

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