LDpred: (March 2015) The LDpred software can be downloaded here. LDpred (Vilhjalmsson et al. 2015; Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores) is a method for computing polygenic risk scores from summary association statistics while accounting for LD between markers. The method infers the posterior mean causal effect size of each marker using a non-infinitesimal prior distribution on effect sizes and LD information from an external reference panel.
Keywords for this software
References in zbMATH (referenced in 1 article )
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- Zhao, Sihai Dave: Integrative genetic risk prediction using non-parametric empirical Bayes classification (2017)