SimBoolNet is an open source Cytoscape plugin for simulating the dynamics of signaling transduction using Boolean networks. In a Boolean network, every node is assigned a state of ON/OFF, and the state of a node is determined by the states of its up‐stream neighboring nodes (i.e. nodes that are connected by an incoming edge). Given user‐specified levels of stimulation to a signaling network, SimBoolNet simulates the responses of the downstream molecules. The process can be visualized with an animation and the results recorded for further analysis. SimBoolNet is a useful tool for hypothesizing causal relation and crosstalk among signaling molecules.

Keywords for this software

Anything in here will be replaced on browsers that support the canvas element

References in zbMATH (referenced in 2 articles )

Showing results 1 to 2 of 2.
Sorted by year (citations)

  1. Madrahimov, Alex; Helikar, Tomáš; Kowal, Bryan; Lu, Guoqing; Rogers, Jim: Dynamics of influenza virus and human host interactions during infection and replication cycle (2013)
  2. Zheng, Jie; Zhang, David; Przytycki, Pawel F.; Zielinski, Rafal; Capala, Jacek; Przytycka, Teresa M.: Simboolnet - a cytoscape plugin for dynamic simulation of signaling networks (2010) ioport