LOT

LOT: a tool for linkage analysis of ordinal traits for pedigree data. Summary: Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage. Availability: The LOT program is available for download at http://c2s2.yale.edu/software/LOT/

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References in zbMATH (referenced in 2 articles )

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  1. Zhang, Heping: Statistical analysis in genetic studies of mental illnesses (2011)
  2. Zhang, Meizhuo; Feng, Rui; Chen, Xiang; Hu, Buqu; Zhang, Heping: LOT: a tool for linkage analysis of ordinal traits for pedigree data. (2008) ioport