Medical knowledge grows exponentially. Thus the improvement of patient care by capturing this knowledge in a computable environment is a decisive challenge of medical informatics. In the German-Brazilian cooperation project Cyclops we try to build an integrated solution in order to cope with this task. In this paper we describe the POKMAT system, a process oriented knowledge management tool and its application to medical examination guidelines. The system is developed in close cooperation with private radiological hospitals in Germany and Brazil. We try to improve the daily work of our medical partners by the integration of the tool into the hospitals environment via DICOM interfaces. Another aim is an easy knowledge exchange between the medical partners in both countries. POKMAT should act as an Organizational Memory of the practice