In the last years, the Simulated Moving Bed (SMB) technique has increasingly been applied to isolate and purify high-valued pharmaceutical substances or fine chemicals and biotechnology products. SMB-processes are governed by mixed continuous and discrete dynamics and exhibit a complex behavior due to nonlinear multi-component adsorption. Such processes cannot be easily designed and operated in the optimal way based solely on experience. In order to reduce separation costs and to shorten the overall design and development stages, a new integrated software package for the optimal operation of SMB-Processes is presented in this contribution.